Mice are a common problem in honey bee colonies. They often will make nests inside hives with or without bees. Most instances occur during the fall, when the evening temperatures begin to drop. Mice will destroy the frames and wax comb by chewing on them to create more area for their nest. Although the destruction of the hive is a big problem, another problem from mice infesting hives is that their urine and droppings often cause bees to abandon the hive.